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Special sequence design, large-capacity library construction, and unlimited screening provide you with one-stop molecular discovery services.
mRNA display technology has proven to be a powerful tool for peptide design, protein engineering, and studying protein interactions. Its ability to screen vast libraries of candidate sequences far surpasses all in vivo methods and most other in vitro techniques. A key advantage is the seamless incorporation of unnatural amino acids into the protein library, unlocking the potential for novel structures and activities that cannot be generated through other methods.
The covalent genotype-phenotype linkage unique to mRNA display not only simplifies the identification and recovery of selected candidates but also supports a wide range of selection conditions. This robustness is especially valuable for enzyme engineering, allowing the evolution of soluble, properly folded, heat-stable proteins that can withstand organic solvents, extreme pH levels, or high salt concentrations—conditions often incompatible with in vivo methods.
Our mRNA display technology is an in vitro peptide/protein screening technology that fuses genotype (mRNA) with phenotype (protein) for biomolecular ligand discovery and interaction analysis. There are 6 main steps in mRNA display technology, in which the core element is puromycin, and the core step is the formation of mRNA-protein complexes by puromycin.
The multi-application molecular discovery platform based on mRNA display technology developed by CD BioSciences will continue to provide professional services to global clients to facilitate drug discovery and basic research in the life sciences.
The mRNA is linked to the antibody obtained in the process of translation in vitro through puromycin, and then reversely transcribed to form a ternary complex and bind to the target protein. Antibody screening was completed in a cell-free system, and target antibodies with high affinity and specificity were obtained through multiple rounds of elutriation.
| Services | Types |
| mRNA Display-based Antibody Library Construction | |
| mRNA Display-based Antibody Screening | |
| mRNA Display-based Antibody Affinity Maturation |
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The high-throughput peptide discovery platform based on mRNA display technology can quickly and efficiently screen and verify relevant target peptide molecules for multi-mechanism research. Our services include a one-stop development process from sequence design to enrichment and validation of target molecules, and follow a strict quality control system to ensure the delivery of high-quality products and related results reports.
| Services | Types | |
| mRNA Display-based Peptide Library Construction | Unnatural Peptide Library Construction | |
| mRNA Display-based Peptide Screening | ||
| mRNA Display-based Peptidomimetic Development | Different Targets |
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| Different Diseases |
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| Different Functions |
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The research and discovery of proteins can provide more direct evidence for complex life phenotypes that are difficult to explain by genes. mRNA display technology can be used to completely produce, select, and evolve these proteins in vitro, not only to synthesize antibodies but also to discover a variety of functional proteins and enzymes.
| Services | Applications |
| mRNA Display-based Protein Screening | Cell epitopes, GPCR ligands, enzyme substrates, cell signals, etc. |
| mRNA Display-based Self-Assembling Protein Microarray Development | Protein expression profiles, protein-protein/DNA/RNA interactions, protein targets for drug action |
| mRNA Display-based Unnatural Protein Development | Protein engineering and protein drug production |
| mRNA Display-based Enzyme Directed Evolution | Food industry, medicine and health, fine chemicals, bioenergy |
Professional Team
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High Reputation
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One-Stop Solutions
We can provide one-stop solutions to reduce project costs and timelines.
Abundant Experience
We take great pride in our experience in mRNA display research and drug development.
Quality and Reliability
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