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Most biomaterials are derived from natural components with different sequences and structures, resulting in complex shapes, scaffolds and chemical properties with customizable functions. However, it also has certain limitations, such as toxicity and poor biocompatibility. In order to meet some special needs, people have developed a variety of biomaterials, such as creating specific secondary structures or biocompatible surfaces with ideal characteristics, and intelligent materials for imaging, bioelectronics, biosensors and molecular recognition applications. Through high-throughput in vitro screening technology, various naturally difficult to produce small molecular compounds with special structure can be developed, and through unique modification technology, more functions can be given, and applied in biochemistry, medicine, industrial production and other related materials.
A variety of functional molecules can simulate the mechanical, topological and biochemical characteristics of natural tissue microenvironment through supramolecular assembly, and synthesize materials widely used in biomedicine, food science, environmental science and agriculture. CD BioSciences is committed to using mRNA display technology to achieve the screening and development of multiple functional small molecules and to integrate them into the development of a variety of engineering materials to meet people's needs.
Biomaterials based on tissue engineering and regenerative medicine can simulate extracellular matrix (ECM) in three-dimensional networks to promote cell adhesion and proliferation. These materials must be viscoelastic, capable of forming hydrogel networks to physically support cells; It also has biochemical characteristics to allow cells to adhere to the network or target specific sites. For example, peptide mimics found through mRNA display, self-assembly β-Tablet peptides have been used as very effective ECM simulation materials.
Functional small molecular materials can also be used for local delivery of various therapeutic agents. Traditional systemic drug delivery methods often lead to unnecessary targeted toxicity. Peptide materials discovered by mRNA display technology can be used as biocompatible controlled drug delivery systems to reduce dose. Therefore, supramolecular peptide systems with multivalent display motifs can target delivery sites or selectively activate drug release. Several self-assembled peptide systems have been reported as carriers for delivering drugs or drug peptide conjugates.
Many biological preservatives from natural and anti-microbial sources have been used as polymers in the food packaging industry. However, their interaction with certain food components (protein and fat) and their stability (such as protein hydrolysis and degradation) may lead to decreased antibacterial activity. On this basis, further optimize the functional characteristics of antimicrobial peptides through mRNA display technology, such as modifying or removing its sensitive parts to improve its stability, which will be conducive to its wide application in the food packaging industry.
Among a variety of environmentally friendly biodegradable materials, biomaterials based on protein development have received particular attention. In recent years, the modified preparation of functional protein materials has gradually become a research hotspot in the field of environment. It has excellent processing properties and mechanical properties in the process of injection molding, extrusion and blow molding. The protein with ideal functional properties can be synthesized by mRNA display technology and modified to achieve easy degradation, environmental friendly, and widely used in many fields.
CD BioSciences is committed to discovering a variety of functional compounds through mRNA display technology for material research in multiple fields such as tissue engineering, food engineering, and biomedicine. If you have any applications or services you want to know, please contact us immediately for the best suggestions and solutions.
